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Only SBIR Phase I awardees are eligible to participate in subsequent phases

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Based on the findings of this study and in accordance with the recommended methods outlined in the C28-A3 and WS/T 402-2024 guidelines, we established gender-specific reference intervals for serum GR activity in apparently healthy adults in eastern China: 26.651.8 U/l for males and 29.755.3 U/l for females

The weight-loss effect of GLP-1RAs also benefits NASH improvement, by reducing appetite and increasing energy expenditure to promote weight loss, thereby indirectly ameliorating NASH.206,512 Thus, GLP-1 and its agonists slow down the progression of NASH and may positively impact the reversal of liver fibrosis.513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism