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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level

Adamek G, Felix R, Guenther HL, Fleisch H: Fatty acid oxidation in bone tissue and bone cells in culture

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through an analysis of human CSF samples, observed a 23% reduction in CSF ApoJ concentrations in patients with mild cognitive impairment (MCI) compared to control groups, with a similar declining trend in AD patients [13]