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This delay is because the gut is involved and the hepatic loop takes 3 - 48 hours to cycle through your portal vein, liver, bile, small intestine and ilium

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Design and preparation of microneedle array Design principles of microneedle array The design of microneedle array needs to consider the following factors: Needle length and diameter Needle length and diameter need to be optimized based on drug properties, skin characteristics, and treatment needs