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While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

This trial was also pioneering internationally on the subject of diabetic nephropathy and the effect of thiamine supplementation on it

Using high-powered MRS, the team was able to identify glutathione (among other brain chemicals) in a group of human subjects: 81 with recently diagnosed first-episode psychosis and 91 healthy controls