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The trials included individuals with overweight (BMI 27 kg/m 2 ) and 1 weight-related complication, including dyslipidaemia, hypertension, sleep apnoea, impaired glucose tolerance and/or impaired fasting glucose and type 2 diabetes, or individuals with obesity (BMI 30 kg/m 2 ) with or without complications

Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States There are several possible explanations for these associations

Coddou C, Yan Z, Stojilkovic SS (2015) Role of domain calcium in purinergic P2X2 receptor channel desensitization

While results vary, clinical studies on the abdomen and flanks have shown average waistline reduction was about one dress or pant size (about one inch), with some patients losing up to two and one-half inches