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Some formulations, like semaglutide, which is 94% similar to the natural GLP-1 hormone, can also trigger reactions

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However, carriers of the homozygous and heterozygous genotypes (TT and CT, respectively) UGT2B7*2 had lower plasma concentrations of VPA compared to carriers of the homozygous CC genotype, suggesting that carriers of the TT and CT genotypes may require higher doses of VPA [5]