european medicines agency glp-1 vision loss recommendation november 2025 The expanding landscape of EU actions to tackle shortages

Peri-procedure aspiration risk: Due to delayed gastric emptying, I advise stopping agents at least 12 weeks before anesthesia or deep sedation

Data from 261 NASH patients receiving repeated liver biopsies showed that weight loss, the absence of diabetes, ALT normalization, and baseline NAS less than 5 were independent predictors of NASH resolution without fibrosis worsening after 1 year of lifestyle intervention [91]

Insulin requirements can be high in patients with compensated cirrhosis, whereas they can be low in decompensated patients due to a reduction in hepatic clearance and gluconeogenesis.84 Because of this, it is recommended that the administration of insulin in patients with cirrhosis should start with close monitoring due to the risk of hypoglycemia.85 The pharmacokinetic of short-acting insulin analogues such as insulin lispro, aspart and glulisine is not significantly altered as a result of hepatic dysfunction

What is the difference between tirzepatide and semaglutide