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The knee ligaments (ACL, PCL, MCL, LCL) that provide knee stability can become lax, especially in advanced stages, causing sensations of giving way, affecting knee alignment and potentially causing bone deformity

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This alteration is accompanied by reduced expression of pro-inflammatory cytokines and adipogenic genes, smaller adipocytes, and increased markers of adipose tissue browning, ultimately attenuating obesity-associated inflammation (Macchi et al., 2022a)