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Since subcutaneous adipocytes typically display lower densities of GH receptors than visceral adipocytes, they may not respond as well to GH-induced or Frag 176-191-mediated lipolysis, possibly resulting in differential regional adipose mobilization

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pH and ionic environment These conditions affect charge, solubility, reaction rates, and intermolecular forces

47 In addition, rodent GH does not activate the human or primate GHR, so the use of pegvisomant in animal models of disease does not address the effect of the blockade of systemic GH