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Chronic constipation patients have reduced EC cell density, decreased 5-HT synthesis, and significantly lowered colonic tissue 5-HT concentrations ( 3.2.2 Neuroendocrine alterations Neuroendocrine system dysregulation represents an important pathophysiological mechanism in chronic constipation and depression comorbidity, involving abnormalities in the HPA axis, hypothalamic-pituitary-thyroid (HPT) axis, and various gastrointestinal hormones (Konturek et al., 2011)
Higher overall GI rate than semaglutid
Unlike severe calorie-restriction diets that trigger metabolic adaptation and energy-conservation responses, GLP-1 therapy largely avoids this 'metabolic slowdown' because you're not creating dangerous energy deficits
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