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For example DPP4is and GLP1RAs both target the incretin pathway, which has been investigated since the 1960s for its involvement in postprandial energy metabolism (97)

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What GLP-1 Medications Do to Your Body GLP-1 receptor agonists work by mimicking a hormone that: Reduces appetite significantly most users eat significantly less food Slows gastric emptying food sits in your stomach longer, making you feel full Affects taste preferences many users lose interest in fatty or sugary foods Creates calorie deficit leading to rapid weight loss The GLP-1 Protein Challenge Most GLP-1 users struggle to eat enough protein because they simply aren't hungry

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