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When starting creatine, you can either use a loading phase of 20g per day split into four doses for five to seven days to saturate muscles quickly, then drop to 35g daily maintenance, or skip loading entirely and reach saturation within three to four weeks at the maintenance dose

Side effects like nausea or diarrhea are possible

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Methods: A PRISMA-guided systematic review was conducted using PubMed and MEDLINE databases with search terms glutathione AND topical AND skin OR dermatology. From 446 articles, only clinical trials on topical glutathione were included, excluding reviews, animal studies, and research on oral or intravenous glutathione