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Women who address sleep quality alongside GLP-1 treatment consistently report better outcomes than those managing medication alone

Tirzepatide reduces appetite, energy intake, and fat mass in people with T2D (abstract)

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Mechanistically, T3 acts to alter the BA composition by targeting CYP8B1, a sterol 12-hydroxylase required for CA synthesis, and then the subsequently altered BA profiles, particularly the increased non-12-OH FXR-antagonistic BAs, potentiates the GLP-1 production and insulin secretion by repressing FXR signaling