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Yu J, Wang Y, Yan F, Zhang P, Li H, Zhao H, Yan C, Yan F, Ren X

490 Excessive inhibition of Nrf2 may not improve DOX-induced cardiomyopathy due to insufficient promotion of antioxidant gene expression, while its overactivation increases the breakdown of heme and ferrous iron levels in the HO-1-catalyzed manner, promoting ferroptosis

Microglia, under normal physiological circumstances, offer neuroprotection by the release of neurotrophic factors and the maintenance of an anti-inflammatory milieu, therefore promoting the wellbeing and optimal functioning of neurons (Maugeri et al., 2021)