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The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida

Heparin sodium and normal saline were obtained from Sinopharm Chemical Reagents Co

But before rolling up your sleeve, stop and ask, what else comes with it

Until these trials report and a regulator reviews them, every retatrutide result remains investigational, with no approval date