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developed an injectable self-healing hydrogel with pH-responsive properties, integrating gold NP-decorated titanium/iron bimetallic organic framework tetragonal nanosheets (Au/TF-MOF TNS) and the chemotherapeutic agent doxorubicin (DOX) for synergistic sonodynamic/chemo dynamic/starvation/chemo-therapy (SDT/CDT/ST/CT) [95]

Oral Supplements In addition to topical applications, GHK-Cu is also available in oral supplement form

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Mechanistically, ROS generated by pyocyanin triggers the release of pro-inflammatory cytokines such as the neutrophil chemotactic factor IL-8 in a NF-B-dependent manner through the MAPK/ERK signaling (98, 99), further contributing to the pathological effects observed during P