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Liver slices from mice exhibited marked liver injury when incubated with acetaminophen, which was accompanied by extensive metabolism of the drug and by glutathione conjugate formation (demonstrating that metabolic bioactivation had occurred), while mouse liver slices that were incubated with equivalent doses of AMAP exhibited a markedly reduced extent of injury and did not generate detectable levels of glutathione conjugates

For RNAi (knockdown, KD) experiments, Sororin siRNAs were described previously (Schmitz et al, 2007)

Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase

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