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Much has changed since 2020, but much has not

Patients should be informed that a modest heart rate increase is an expected effect of GLP-1 therapy and does not typically indicate a problem

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Semaglutide for Fat Loss | STEP Program Data Semaglutides FDA approval for weight loss and chronic weight management was based on the results of phase-3 trials conducted as a part of an ongoing clinical development program called STEP (Semaglutide Treatment Effect in People with Obesity), sponsored by semaglutide's patent holder Novo Nordisk [13]