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Participants in the oral semaglutide arm underwent a dose-escalation schedule (3 mg daily for 4 weeks, followed by 7 mg daily for 4 weeks, then 14 mg daily for the remainder of the trial) to minimize gastrointestinal side effects

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Furthermore, longitudinal studies of anti-psychotic treatment effects on ACC glutamate mostly report that baseline differences from controls [37, 38] or within the patient group, do not change significantly over a minimum of 6 weeks treatment to 6 months or more [39, 40]

However, early evidence suggests potential renal benefits