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Long-term effects include brain damage, liver disease, and permanent cognitive impairments

Who may need high dosages of B12: People with absorption difficulties due to insufficient stomach acid, lack of intrinsic factor (pernicious anemia), or gastrointestinal surgery 6 Vegans/strict vegetarians People affected by certain genetic variants, e.g

In adults over 55, prolonged-release melatonin improved sleep quality and morning alertness in a randomized trial of 354 people [6]

Dietary Supplementation with Glycine Enhances Intestinal Mucosal Integrity and Ameliorates Inflammation in C57BL/6J Mice with High-Fat Diet-Induced Obesity Coppola L., et al (1992)