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Similarly, patients with history of retinal detachment, untreated age-related macular degeneration, or other serious retinal conditions should approach GLP-1 use cautiously

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GIP improves the function of white adipose tissue and has an intense anorexigenic impact through the integration of activation signals within the brain [99]

Nevertheless, microdermabrasion with aluminum oxide has no direct role in melasma treatment since it only affects the stratum corneum but may facilitate the permeation of products [130]