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Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

Because these symptoms span so many body systems and because theres no single gold-standard diagnostic test histamine intolerance is frequently misdiagnosed or missed entirely