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Although the exact mechanism of cyclosporine nephrotoxicity remains unknown, its administration has been associated with in vivo reduction of GSH concentrations in the livers and kidneys of rats, which may be related to adverse effects of this immunosuppressive agent
Ipamorelin's durable contribution, as recognized in the primary literature, is its demonstration that GHS-R1a agonism could be pharmacologically dissociated from co-stimulation of the hypothalamic-pituitary-adrenal axis, evidence of signal diversity at the receptor that informed subsequent compound design
Diabetes 56 , 20162027 (2007)
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