Migraine without aura, migraine with aura, chronic migraine, episodic migraine, vestibular migraine, hemiplegic migraine, these are all distinct conditions with overlapping but different pathophysiology
GLP-1 naturally declines
I dont know for certain but while Lilly and Novo made these GLPs 1x weekly for compliance purposes and relied on the long half life, twice weekly makes more sense in terms of AUC, CMax and avoiding peaks as well as uncomfortable effects
When to seek immediate medical attention Regardless of which tirzepatide formulation you have used or are currently using, seek immediate medical care if you experience: Severe abdominal pain that does not resolve (potential pancreatitis) Signs of allergic reaction including swelling, difficulty breathing, or widespread rash Persistent vomiting lasting more than 24 hours Signs of dehydration including dark urine, dizziness, and rapid heartbeat Vision changes (potential thyroid concerns) Severe joint pain or muscle pain that interferes with daily function These symptoms warrant professional evaluation whether you are on injectable, oral, or any other formulation of tirzepatide or GLP-1 medications
