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Riboflavin, in the cofactor FAD, is an important cofactor for several antioxidant enzymes, but it will be covered in more depth in the macronutrient metabolism micronutrients chapter (Chapter 10)

3.4.4 Summary Preclinical studies consistently demonstrate that metformin attenuates DOX-induced cardiotoxicity through coordinated modulation of oxidative stress, mitochondrial dynamics, autophagy, apoptosis, and inflammation

Low-dose regimens have shown strong cognitive benefits with minimal side effects Early research supports its use for cognitive enhancement, mitochondrial support, fatigue, and inflammation

The B55 subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation