Back to Journals Drug Design, Development and Therapy Volume 9 Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro Authors Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W , Wang Y, Zhang Y, Zhang W Received 2 February 2015 Accepted for publication 10 March 2015 Published 30 April 2015 Volume 2015:9 Pages 24852499 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 5 Editor who approved publication: Professor Shu-Feng Zhou Tonglie Huang, 1,* Kuo Zhang, 2,* Lijuan Sun, 3 Xiaochang Xue, 1 Cun Zhang, 1 Zhen Shu, 1 Nan Mu, 1 Jintao Gu, 1 Wangqian Zhang, 1 Yukun Wang, 1 Yingqi Zhang, 1 Wei Zhang 1 1 State Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, The Fourth Military Medical University, 2 National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, 3 Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, Xian, Peoples Republic of China * These authors contributed equally to this work Abstract: Chemical burns take up a high proportion of burns admissions and can penetrate deep into tissues
By inhibiting NNMT, 5-Amino-1MQ is theorized to spare nicotinamide for NAD+ synthesis , raising intracellular NAD+ and activating SIRT1 (Sirtuin 1) pathways tied to mitochondrial biogenesis and fat oxidation [3]
A Hariz, PT Bhattacharya
Orally bioavailable
