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Other side effects that can occur include: Excessive sweat production Rapid weight gain Pain when breathing Shortness of breath when lying down Anxiety Increased or irregular heart rate Numbness, tingling or muscular weakness Increased thirst Urinary frequency B12 injections can also cause allergy symptoms immediately after administration, like difficulty breathing, a swollen throat, mouth, or swelling of the mouth, tongue or face

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Semaglutide trials, by contrast, measure weight loss as a primary outcome, track metabolic changes, and monitor safety across thousands of participants over months

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