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doi:10.1007/s00441-019-03016-8 [2] Deek SA

The estimated hazard ratio for time to first MACE was 0.86 (95% CI: 0.77, 0.96) over the median follow-up duration of 49.6 months and 49.4 months for patients randomized to RYBELSUS and placebo, respectively

PlexusDx recommends baseline liver and homocysteine screening for patients considering this combination

Moreover, recent clinical studies and real-world clinical data have revealed broader pleiotropic effects of these drugs , opening doors for repurposing and extending the commercial lifespan of these drugs