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In type 1 diabetes, combination therapies have primarily focused on glucose control and safety, with several randomized controlled trials investigating the effects of combining treatments such as SGLT2is and GLP-1RAs with insulin

In addition to its activity against hyperglycemia, DPP-4i has shown beneficial cardiovascular effects including cardioprotective action, endothelial protection, and an anti-hypertensive effect

This pattern may trigger fatigue, dizziness, or renewed hunger signals that contradict the appetite suppression you expected from your medication

The experts concurred that the differences in the action mechanisms may partially explain these results and could also help mitigate the undesirable cardiovascular physiological effects such as the increase of heart rate