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This three-step approach for estimating HLA binding of sequences containing unnatural amino acids in silico has been described in greater detail previously ( Having defined the approach to handling unnatural amino acids in selected impurities, EpiMatrix was used to identify T-cell epitopes in the sequences of the TPT API and 34 impurities ( Figure 4 )

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However, with seven additional Phase 3 trials expected to wrap up in 2026, experts believe it could soon become a major option for people with significant weight loss needsespecially those managing obesity-related joint pain