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Although findings are not always steady, an increase in lipid peroxidation and in nitric oxide levels have been reported in BD patients, as well as increased damage in deoxyribonucleotide acid (DNA) and ribonucleic acid (RNA), compared with healthy controls [42]

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En Amrica Latina la mayora de la causalidad atribuible es dada, adems, del tabaquismo, por: obesidad abdominal, dislipidemia, hipertensin arterial y Diabetes Mellitus tipo 2 (DM2), conjunto de alteraciones que conforman el denominado Sndrome Metablico y que en Latinoamrica es de particular importancia por su alta prevalencia que llega a ser de ms del 35%3