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En septembre 2025 , l' OMS a ajout plusieurs analogues du GLP-1 (smaglutide, dulaglutide, liraglutide) et le tirzpatide sa Liste des Mdicaments Essentiels pour la prise en charge des adultes atteints de diabte de type 2 prsentant une maladie cardiovasculaire ou une maladie rnale chronique tablie, et une obsit (IMC 30)

10.1111/j.1476-5381.2009.00441.x [DOI] [PMC free article] [PubMed] [Google Scholar] Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, DAlessio DA, Haupt A (2018) LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept