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Eur J Pharmacol 982: 176936

3.2.3 Endoplasmic reticulum pathway The endoplasmic reticulum (ER) is essential for protein folding, processing, and intracellular Ca 2+ homeostasis

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We treated TC1-6 cells with serum collected from WT or GCGR-KO mice for 72 h and found that VGF and proglucagon protein levels were significantly increased in GCGR-KO serum-treated cells (Fig