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An important consideration with respect to the ability of GSHee to prevent the deleterious effects of fentanyl on breathing was that the opioid appeared to elicit its full sedative effects in the presence of the GSHee (e.g., righting-reflex times and general observations of behavior could not discriminate between the effects of fentanyl in vehicle-treated or GSHee-treated rats)

Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on December 17th, 2025

Using metabolomics analysis, we found that specific metabolites, including linoleic acid, vaccenic acid, and ethyl pentadecanoate, were only identified in the culture supernatants of L