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Binding leads to a rotational change in the receptor transmembrane domain, which leads to transphosphorylation and activation of two JAK2 molecules that are associated with the cytoplasmic domain of the receptor

Medications: Certain long-term medications can interfere with glutathione production or increase its consumption

While the FDA did not conclude that the drugs caused those events, the warning letter reflects the level of scrutiny these medications now face from federal regulators