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[19] [20] Most patients find that nausea, when present, is transient and diminishes significantly within the first few weeks as the body adapts

Moreover, metformin can inhibit carbon tetrachloride-induced hepatotoxicity, possibly connected with the increase in glutathione in hepatocyte mitochondria [186]

Originally, GLP therapies were prescribed to help people with type 2 diabetes: Improve insulin secretion Reduce glucagon release (which raises blood sugar) Slow gastric emptying Stabilize post-meal glucose spikes These effects made GLPs incredibly effective for glycemic control