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A study on spinal cord injury demonstrated that the introduction of lactate significantly augments lactylation levels in microglia, effectively inhibiting the expression of pro-inflammatory mediators such as IL-1, iNOS, and TNF- [57]

Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has recently emerged as a highly promising and innovative therapy, demonstrating substantial and sustained weight loss [11,12,13]

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This finding corresponds with the current study, where both groups showed significant P-values, but the dermaroller with copper peptide group had a more substantial p = 0.001 as mentioned in Table 1