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Additionally, obesity-associated systemic low-grade inflammation could cause an elevation of inflammatory cytokines and chemokines in circulation together with the accumulation and impaired function of various immune cells including macrophages and B cells in pancreas, resulting in islet inflammation and -cell dysfunction (Eguchi et al

10.1038/nrclinonc.2011.121 Nat

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It has been approved by regulatory authorities for the treatment of type 2 diabetes and has demonstrated effectiveness in lowering the risk of cardiovascular death in individuals with existing cardiovascular disease and type 2 diabetes