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Carlsen MH, Halvorsen BL, Holte K, Bhn SK, Dragland S, Sampson L, Willey C, Senoo H, Umezono Y, Sanada C, Barikmo I

In the body we have several enzymes with antioxidant properties such as superoxide dismutase, catalase, glutathione reductase and peroxidase, among others, which require various cofactors to fulfil their function

These findings are consistent with the hypothesis that excitotoxicity during the acute phase of illness leads to reduced glutathione and glutamate in the residual phase of the illness

The combination of amylin and GLP-1 agonism may become a standard approach for obesity treatment, potentially displacing monotherapy as first-line pharmacological intervention