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Retatrutide's Mechanism and Other Comparisons Retatrutide stands out as a triple agonist, acting on GLP-1, GIP, and GCG, whereas other alternatives like tirzepatide work only on GLP-1 and GIP receptors

The significant reduction in urinary oxalate excretion after weight loss through GLP-based therapies could possibly be attributed to decreased intake of oxalate and oxalate precursors or to reduced hepatic oxalate synthesis

(PubMed) Karanikas G, Schuetz M, Kontur S, et al

However, the medication's labeling includes specific pregnancy guidance, and significant weight changes can influence reproductive function through indirect pathways