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Contraindications to tranexamic acid History of coronary stent(s) History of active hematuria (it is thought that administration of TXA in the patient with hematuria may cause a clot resulting in obstructive uropathy) History of venous thromboembolic disease Update 2020 : An international randomized placebo-controlled trial involving 12,009 patients examined the role of tranexamic acid in acute gastrointestinal bleeding, with primary outcomes including death within 5 days and thromboembolic events

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