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Some argue that prolonged activation of pancreatic GLP-1 receptors could lead to an overgrowth of cells in the organ

However, their effectiveness is highly dependent to patient breathing pattern and requires patient coordination between actuation of the device and the breath pattern

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A few commenters encouraged CMS to support data infrastructure improvements, such as automating quality reporting, aligning state reporting standards, and exploring use of the Trusted Exchange Framework and Common Agreement (TEFCA) for data sharing