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Additionally, immune-related pathways were activated in the long term, with a short-term upregulation of inflammatory markers, such as interleukin ( IL)-6 and IL-18 , although the levels of matrix metalloproteinases (MMPs) remained stable, indicating that not only complex inflammatory stimuli, but also oxidative stress responses can disrupt ECM homeostasis

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Mutat Res 390:141151 Fang J, Nakmura H, Iyer AK (2007) Tumor-targeted induction of oxystress for cancer therapy