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However, studies have shown that antioxidant approaches, including anti-neuroinflammatory and neuroprotective agents, may have therapeutic efficacy in the treatment of PD (Balestrino and Schapira, 2020)

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doi: 10.1186/s40560-020-00453-4 122 HunterD

Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al