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Beyond weight, the SELECT trial (N=17,604) published in the New England Journal of Medicine in 2023 showed that semaglutide 2.4 mg reduced major adverse cardiovascular events (MACE) by 20% compared to placebo in adults with overweight or obesity and established cardiovascular disease, over a median follow-up of 39.8 months (HR 0.80 to 95% CI 0.72 to 0.90)
The two require separate evidence
Laboratory protocols demonstrate that under optimal dosing conditions, the peptide eliminates senescent cells while destroying an undetectable number of healthy cells, representing exceptional selectivity compared to earlier senolytic approaches
Towards an understanding of the genetics of tendinopathy
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