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Furthermore, weight loss is likely to remain a concern in non-diabetic patients, particularly if they are already frail or undernourished, and especially in the context of the semaglutide trial, given its enhanced efficacy in promoting weight reduction [39]

Non-pharmacological Interventions: Exercise A growing body of preclinical and clinical evidence supports the benefits of exercise in PD: epidemiological studies have found a reduced risk of PD among healthy individuals who are more physically active [217], as well as an improvement in off-medication gait parameters [218] and a delay in the progression of some PD signs and symptoms [219] and reduced mortality in physically active patients with PD [220]