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In addition, RAM contains particular cell types, as well as extracellular matrix molecules which are vitally distinct from those found in healthy sites, including inflammatory factors, reactive oxygen and nitrogen species (RONS), immunogenic proteins, and oxygen [8, 9]

Nov 15 2016;30(11)

fALS mouse models have an increased neuroprotective M2 microglial response in the initial phase of disease, but a mostly neurotoxic M1 response at end-stages [117], with production of NO depending on NOX2, pro-inflammatory cytokines (IL-6, IL12, IL-23, TNF) and H 2 O 2 ([117]

Glutamic pyruvate aminotransferase 2 (GPT2) is a key enzyme in the Gln decomposition pathway (61)