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Our data not only unveils a previously unknown pathway of ERMCS-localised GPCR signalling into mitochondria, potentially applicable to other GPCRs beyond the GLP-1R, but also opens the door to further roles of the GLP-1R in the regulation of mitochondrial lipid metabolism, a process tightly linked to changes in mitochondrial morphology governed by MICOS complex activity 10

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However, no direct link has been found between GLP-1R agonists and higher pulmonary aspiration risk