[8] Findings show that abnormalities in permeability barrier function in KP likely reflect an impairment in lamellar bilayer (LB) architecture
Thyroid issuesmost commonly hypothyroidism, hyperthyroidism, and, less frequently, thyroid stormare the most commonly reported endocrine toxicity following ICI medication in clinical trials (Barroso-Sousa et al
2.4 Antioxidants and polyphenols Antioxidants and polyphenols represent a diverse group of bioactive compounds with potential relevance in breast cancer management ( in vitro and animal models ( 2.4.1 Flavonoids Natural goods contain flavonoids, a class of chemicals with many bioactivities such as antibacterial, antioxidant, antimalarial, & antiallergic/anti-inflammatory properties ( 2.4.2 Puerarin The isoflavone puerarin, derived from the dried root of kudzu ( Radix puerariae ), has a long history of use as a medicinal ingredient in traditional Chinese medicine ( Research has shown that puerarin can inhibit the division of breast cancer cells by reducing the cell death rate and increasing the synthesis of anti-apoptotic proteins via the ER signalling pathway, in contrast to pro-apoptotic proteins ( in vitro adhesion of LPS-treated MCF-7 and MDA-MB-231 cells to the extracellular matrix (ECM) was significantly reduced, and the cell-adherence components ICAM and VCAM were downregulated
Most importantly, their potential application in treating central nervous system disorders and allergic rhinitis, particularly via the nasal route, has become a major focus of current research with a significant body of evidence
