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Notably, key transcription factors (e.g., Nrf2 and HIF-1) act as critical regulatory checkpoints within this network: Nrf2 inhibits ferroptosis and inflammation by upregulating GPX4 and antioxidant enzymes, while HIF-1 exerts a context-dependent dual role, acutely mitigating ferroptosis via Nrf2 activation but promoting fibrosis and sustained ferroptosis when chronically stabilized

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This means that even sunscreens that protect against skin cancer aren't enough to ward off melasma, says Dr

General practitioners are increasingly initiating these therapies, often in response to patient demand or as part of broader cardiometabolic risk management